immortalization

Telomere and telomerase are the focus of modern biological study. There are close relationships among telomere loss and cell ageing, activation of telomerase, cell senescence and immortalization.

端粒和端粒酶是现代生物学研究的热点，端粒的缺失与细胞的衰老，端粒酶的活性与细胞的老化及癌化均有密切的关系。

The reversible immortalization of human melanocytes mediated by SV40 T antigen gene and Cre/ loxP system

SV40TAg基因和Cre/loxP系统诱导正常人黑素细胞可逆性永生化的初探

Objective: Telomerase is a ribonucleoprotein complex that synthesizes telomeric DNA onto chromosome ends using its RNA component as template, enabling extension of cell lifespan and even immortalization.

目的：端粒酶是一种核糖核蛋白复合物，能以自身RNA成分为模板催化染色体末端端粒重复序列的延伸，使细胞得以持续增殖甚至永生化。

Although the Mongolian national minority already realizes to life finiteness and the temporary, They still pursue the life infinite and eternal, hence became the idea of "soul immortalization".

蒙古族虽然早已熟习到性命的有限性和短暂性，但是，他们依然追求“性命”的无限与永恒，于是形成了“灵魂不灭”的观念。

Long-term Culture and Immortalization of Human Fetal Pancreatic Ductal Cells Transfected by SV40 T Gene

人胚胰腺导管上皮细胞的体外长期培养及永生化

Thereby establishing the immortalization of human mesenchymal stem cells.

从而建立了永生化的人骨髓间充质干细胞。

Immortalization of cultures derived from primary breast carcinoma by ectopic expression of human telomerase reverse transcriptase and its significance

端粒酶永生化原始乳腺癌组织来源细胞及其意义

Immortalization of embryonic fibroblasts in heat shock transcription factor 1 knockout mouse

HSF1基因敲除小鼠胚胎成纤维细胞的永生化

In experiments, immortalization can be achieved following genetic manipulation of cells in various ways, but in the lymphocytes under study this occurred spontaneously.

实验中，我们可以通过多种遗传操作获得永生化细胞，但此项研究中，淋巴细胞确自发的获得永生化的能力。

Role of SV40 in the immortalization of human odontoblast-like cells

SV40在人成牙本质细胞永生化中作用的初步研究

Objective To construct a new retroviral vector with double-suicide genes and knockout-inducible SV40T gene, with the aim of optimizing immortalization of hepatocytes.

目的构建携带双自杀基因且可诱导敲除SV40T的逆转录病毒载体，优化目前的肝细胞永生化。

Interestingly, immortalization of postselection cells using various methods leads to a dramatic decrease in COX-2 expression.

有趣的是，用不同的方法可以显著减少COX-2在后选择的细胞永生化过程中的表达。

Advance in Hepatocyte Immortalization Strategies

肝细胞永生化策略研究进展

The Functions of Telomerase in Cell Immortalization and Tumorigenesis

端粒酶在细胞永生化和癌变中的作用

The Immortalization and Related Studies of Bone Marrow Stromal Stem Cells; Hepatocytes differentiation and maturation of embryoid bodies derived cells in bioreactor

人骨髓基质干细胞永生化及相关研究生物反应器内EBs来源细胞的肝细胞分化与成熟

As we all know, the biological features of tumor cell were abnormal proliferation and immortalization, which usually expressed as apoptosis deficiency.

众所周知，肿瘤细胞的生物学特征是异常增殖和永生化，常常表现为凋亡不足。

Objective: To investigate the expression and significance of Id gene in lung cancer and immortalization bronchial epithelial cells.

目的：研究Id基因在肺癌和永生化支气管上皮细胞中的表达，探讨其在肺癌细胞中表达的意义。

Objective: Telomeres and telomerase are closely associated with cellular senescence and immortalization.

目的：端粒-端粒酶系统在细胞的衰老、永生化等过程中起着非常重要的作用。

Telomerase is a ribonucleoprotein complex whose function is to add telomere repeats to chromosomal ends to make its stable and cell immortalization.

端粒酶是核糖核蛋白复合体，其丰要功能是增加染色体末端端粒的不断重复以维护它的稳定性和细胞的恶性增殖。

Telomerase and cellular immortalization

端粒酶与细胞永生化

Conclusions HPV16E7 plays an important role in the immortalization of oral epithelial cells induced by HPV16.

结论HPV16E7在HPV16诱导的口腔上皮细胞永生化过程中起了重要作用。

Action and Mechanism of Epstein Barr virus Latent Membrane Protein 1 induced Immortalization of Mouse Embryonic Fibroblasts

EB病毒潜伏性膜蛋白1促原代MEF细胞永生化的作用及机制

Telomere, telomerase and hepatocyte immortalization

端粒和端粒酶与肝细胞的永生化

Telomerase is RNA dependent DNA polymerase, acts to synthesize DNA repeat fragment of telomeres, which is associated with immortalization of cells.

端粒酶是一种RNA依赖的DNA多聚酶，可以合成端粒DNA的重复片段与细胞永生化密切相关。

Immortalization of human ovarian carcinoma cells induced by SV40 T antigen gene

SV40T基因诱导的人卵巢癌细胞永生化

The immortalization is reversible, iNPC could be reversed as primary cell under certain conditions and changed its proliferation characteristics.

永生化具有可逆性，iNPC在一定条件下可逆转成为原代细胞，改变其增殖特性。

Immortalization of endothelial cells differentiated from mouse embryonic stem cells

小鼠胚胎干细胞分化为血管内皮细胞的永生化研究

Conclusion SV40 T antigen gene can successfully induce the immortalization of human melanocytes.

结论SV40T抗原基因可以成功诱导人黑素细胞的转化。

The mouse IEC provided the cell material for the study of cell immortalization.

为小鼠小肠上皮细胞的永生化研究提供较好的细胞材料。

The Study of the Immortalization of Human Bone Marrow Mesenchymal Stem Cells by Transducting Human Telomerase Reverse Transcriptase Gene

转导人端粒酶逆转录酶基因致人骨髓间充质干细胞永生化的研究